Arterial hypertension pathogenesis. Institute for Translational Medicine · Subjects · Pathophysiology 1 · UP MS
Megjelenés éve: Kivonat: Clinical and experimental studies show that age-related decline in circulating insulin-like growth factor-1 IGF-1 levels promotes the pathogenesis of intracerebral hemorrhages, which critically contribute to the development of vascular cognitive impairment and disability in older adults. Yet, the mechanisms by which IGF-1 deficiency compromises structural integrity of the cerebral vasculature are not completely understood.
MCAs of control mice exhibited structural adaptation to hypertension, manifested as a significant increase in wall thickness, vascular smooth muscle cell VSMC hypertrophy, decreased internal diameter and up-regulation of extracellular matrix ECM -related genes.
IGF-1 deficiency impaired hypertension-induced adaptive media hypertrophy and dysregulated ECM remodeling, decreasing elastin content arterial hypertension pathogenesis attenuating adaptive changes in ECM-related gene expression.
Thus, circulating IGF-1 plays a critical role in maintenance of the structural integrity of cerebral arteries. Alterations of VSMC phenotype and pathological remodeling of the arterial wall associated with age-related IGF-1 deficiency have important translational relevance for the pathogenesis of intracerebral hemorrhages and vascular cognitive impairment in elderly hypertensive patients.